Battling the blues: How you react to depression may depend on your gender

When it comes to coping with depression, your gender may play a factor. According to a recent study, researchers found that depression has different effects on the brain activity of male and female patients in certain brain regions. The results suggest that adolescent girls and boys may experience depression differently and that sex-specific treatments might be beneficial.

By 15 years of age, girls are twice as likely to suffer from depression as boys. There are various possible reasons for this, including body image issues, hormonal fluctuations and genetic factors, where girls are more at risk of inheriting depression. However, differences between the sexes don’t just involve the risk of experiencing depression, but also how the disorder manifests and its consequences.

Depressed men are more likely to suffer serious consequences, such as substance abuse and suicide. (Shutterstock)

“Men are more liable to suffer from persistent depression, whereas in women depression tends to be more episodic. Compared with women, depressed men are also more likely to suffer serious consequences from their depression, such as substance abuse and suicide,” said Jie-Yu Chuang, a researcher at the University of Cambridge, and an author on the study. This motivated Chuang and her colleagues to carry out this latest study to find differences between depressed men and women.

They recruited adolescent volunteers for the study, who were aged between 11 and 18 years. This included 82 female and 24 male patients who suffered from depression, and 24 female and 10 male healthy volunteers. The researchers imaged the adolescents’ brains using magnetic resonance imaging, while flashing happy, sad or neutral words on a screen in a specific order. The volunteers pressed a button when certain types of words appeared and did not press the button when others appeared, and the researchers measured their brain activity throughout the experiment.

When the researchers flashed certain combinations of words on the screen, they noticed that depression affects brain activity differently between boys and girls in brain regions such as the supramarginal gyrus and posterior cingulate. “Hopefully, early interventions could alter the disease trajectory before things get worse,” explained Chuang. The study was published in journal Frontiers in Psychiatry.



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